Detecting the Recurrence of Gastric Cancer after Curative Resection: Comparison of FDG PET/CT and Contrast-Enhanced Abdominal CT.
10.3346/jkms.2011.26.7.875
- Author:
Dae Weung KIM
1
;
Soon Ah PARK
;
Chang Guhn KIM
Author Information
1. Department of Nuclear Medicine and Institute of Wonkwang Medical Science, Wonkwang University School of Medicine, Iksan, Korea. akaxan@naver.com
- Publication Type:Original Article ; Comparative Study ; Research Support, Non-U.S. Gov't
- Keywords:
Stomach Neoplasms;
Recurrence;
FDG;
PET/CT;
Contrast-enhanced Abdominal CT
- MeSH:
Aged;
Female;
Fluorodeoxyglucose F18/*diagnostic use;
Humans;
Male;
Middle Aged;
Neoplasm Recurrence, Local/*diagnosis/radiography/radionuclide imaging;
Positron-Emission Tomography/*methods;
Radiopharmaceuticals/*diagnostic use;
Retrospective Studies;
Sensitivity and Specificity;
Stomach Neoplasms/*diagnosis/pathology/surgery;
Tomography, X-Ray Computed/*methods
- From:Journal of Korean Medical Science
2011;26(7):875-880
- CountryRepublic of Korea
- Language:English
-
Abstract:
The purpose of this study was to evaluate the value of fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) for detecting the recurrence of gastric cancer. We performed a retrospective review of 139 consecutive patients who underwent PET/CT and contrast-enhanced abdominal CT (CECT) for surveillance of gastric cancer after curative resection. Recurrence of gastric cancer was validated by histopathologic examination for local recurrence or serial imaging study follow-up with at least 1 yr interval for recurrence of distant metastasis form. Twenty-eight patients (20.1%) were confirmed as recurrence. On the patient based analysis, there was no statistically significant difference in the sensitivity, specificity and accuracy of PET/CT (53.6%, 84.7%, and 78.4%, respectively) and those of CECT (64.3%, 86.5%, and 82.0%, respectively) for detecting tumor recurrence except in detection of peritoneal carcinomatosis. Among 36 recurrent lesions, 8 lesions (22.2%) were detected only on PET/CT, and 10 lesions (27.8%) only on CECT. PET/CT had detected secondary malignancy in 8 patients. PET/CT is as accurate as CECT in detection of gastric cancer recurrence after curative resection, excepting detection of peritoneal carcinomatosis. Moreover, additional PET/CT on CECT could improve detection rate of tumor recurrence and provide other critical information such as unexpected secondary malignancy.
