Serum Kisspeptin Levels in Korean Girls with Central Precocious Puberty.
10.3346/jkms.2011.26.7.927
- Author:
Young Jun RHIE
1
;
Kee Hyoung LEE
;
So Hee EUN
;
Byung Min CHOI
;
Hyun Wook CHAE
;
Ah Reum KWON
;
Woo Jung LEE
;
Jung Hyun KIM
;
Ho Seong KIM
Author Information
1. Department of Pediatrics, Korea University College of Medicine, Seoul, Korea.
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Kisspeptin;
KISS1 Gene;
G-protein Coupled Receptor-54;
Central Precocious Puberty;
Gonadotropin-Releasing Hormone
- MeSH:
Biological Markers/blood;
Child;
Female;
Follicle Stimulating Hormone/blood;
Humans;
Luteinizing Hormone/blood;
Puberty, Precocious/blood/*diagnosis;
Republic of Korea;
Tumor Suppressor Proteins/*blood
- From:Journal of Korean Medical Science
2011;26(7):927-931
- CountryRepublic of Korea
- Language:English
-
Abstract:
Central precocious puberty (CPP) is caused by premature activation of hypothalamic gonadotropin-releasing hormone (GnRH) secretion. Kisspeptin and G-protein coupled receptor-54 system is the essential gatekeeper of the reproductive system, playing a key role in the activation of the gonadotropic axis at puberty. We aimed to determine whether serum kisspeptin may function as a marker for CPP by investigating serum kisspeptin levels in Korean girls with CPP and their prepubertal controls. Serum kisspeptin levels of Korean girls with CPP (n = 30) and age-matched healthy prepubertal controls (n = 30) were measured with a competitive enzyme immunoassay. Serum kisspeptin levels were significantly higher in CPP group than in control group (4.61 +/- 1.78 vs 2.15 +/- 1.52 pM/L, P < 0.001). Serum kisspeptin was positively correlated with peak luteinizing hormone (LH), peak/basal LH ratio and peak LH/follicular-stimulating hormone (FSH) ratio during GnRH stimulation test. CPP is supposed to be triggered by premature increase of kisspeptin. Serum kisspeptin may be used as a marker of CPP. Further studies on KISS1 gene polymorphisms leading to higher risk of premature increase of kisspeptin and upstream regulator of kisspeptin are also needed.
