Value of blood inflammatory markers in the diagnosis of acute appendicitis in children.
- Author:
Dangsheng HUANG
1
;
Ming HAN
;
Yang XIE
Author Information
- Publication Type:Journal Article
- MeSH: Appendicitis; blood; diagnosis; Biomarkers; blood; C-Reactive Protein; metabolism; Child; Child, Preschool; Female; Humans; Inflammation; blood; diagnosis; Interleukin-6; blood; Lymphocyte Count; Male; Tumor Necrosis Factor-alpha; blood
- From: Journal of Southern Medical University 2012;32(8):1154-1156
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the value of serum inflammatory markers in the diagnosis of acute appendicitis (AA) in children.
METHODSBlood samples were collected from 51 children with AA and 16 children with nonsurgical abdominal pain (NSAP) to examine white blood cell count (WBC), serum C-reactive protein (CRP), interleukin-6, and tumor necrosis factor-α (TNF-α).
RESULTSWBC count, CRP, IL-6 and TNF-α increased significantly in children with severe AA (phlegmonous or gangrenous, and perforated appendicitis). ROC curves showed that IL-6 or TNF-α had a greater contribution than WBC count to the diagnosis of severe appendicitis.
CONCLUSIONIL-6 and TNF-α can provide complementary information to assist the clinical decision of emergency operation for children with AA.
