Clarithromycin combined with tanshinone for rhinosinusal and laryngeal radiation injury in patients with nasopharyngeal carcinoma after radiotherapy.
- Author:
Hui LI
1
;
Huadong WANG
;
Yukun MA
;
Jianfu ZHAO
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Carcinoma; Clarithromycin; therapeutic use; Combined Modality Therapy; Diterpenes, Abietane; therapeutic use; Female; Humans; Larynx; pathology; Male; Middle Aged; Nasopharyngeal Neoplasms; radiotherapy; Nose; pathology; Paranasal Sinuses; pathology; Pharynx; pathology; Radiation Injuries; drug therapy; Young Adult
- From: Journal of Southern Medical University 2012;32(8):1168-1170
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the therapeutic effect of clarithromycin combined with tanshinone in the treatment of rhinosinusal and laryngeal radiation injury induced by radiotherapy in patients with nasopharyngeal carcinoma (NPC).
METHODSA total of 255 NPC patients with rhinosinusal and laryngeal radiation injury following radiotherapy were randomized into 3 groups for treatment with clarithromycin (group A, n=69), tanshinone (group B, n=69), and clarithromycin + tanshinone (group C, n=69), and the clinical outcomes of the patients were evaluated.
RESULTSIn all the 3 groups the patients responded favorably to the treatments and showed obvious improvements (P<0.05). The therapeutic effects were similar between groups A and B (P>0.05), but the patients in group C showed the most obvious improvements (P<0.05).
CONCLUSIONSClarithromycin combined with tanshinone can be an effective regimen for treatment of rhinosinusal and laryngeal radiation injury induced by radiotherapy in NPC patients.
