Expression profile of miRNAs in APP swe/PSΔE9 transgenic mice.
- Author:
Yu DING
1
;
Mi TIAN
;
Jianfeng LIU
;
Yanyao DENG
;
Wei LI
;
Xialu FENG
;
Deren HOU
Author Information
- Publication Type:Journal Article
- MeSH: Alzheimer Disease; genetics; metabolism; Animals; Disease Models, Animal; Gene Expression Profiling; Mice; Mice, Transgenic; MicroRNAs; genetics; metabolism; Oligonucleotide Array Sequence Analysis; Transcriptome
- From: Journal of Southern Medical University 2012;32(9):1280-1283
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the changes of miRNA expression profiles in APPswe/PSδE9 transgenic mice and explore the possible roles of miRNA in the pathogenesis of Alzheimer's disease.
METHODSUsing miRNA chip technique, we examined the miRNA expression in the brain tissue of 6-month-old APPswe/PSδE9 transgenic mice, with age-matched wild-type mice as the control group.
RESULTSTwelve miRNAs showed differential expressions by more than two folds in APPswe/PSδE9 transgenic mice, namely miRNA-135a, miRNA-135a-2*, miRNA-298, miRNA-466b-3p, miR-669-3p, miR-142-5p, miR-144, miR-466f-3p, miR-466g, miR-200a, miR-200b and miR-96. Five miRNAs were significantly down-regulated in the transgenic mice, including miRNA-135a, miRNA-135a-2*, miRNA-298, miRNA-466b-3p, and miR-669-3p.
CONCLUSIONThe 5 down- regulated miRNA may play important roles in the pathogenesis of AD in APPswe/PSδE9 transgenic mice.
