Correlation of the expressions of MMPs-9, TIMP-1 and TIMP-2 with cesarean section scar.
- Author:
Qiong LI
1
;
Suiqun GUO
;
Dalie LIU
;
Shuying FENG
;
Qingzhu WEI
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Cesarean Section; adverse effects; Cicatrix; etiology; metabolism; Female; Humans; Matrix Metalloproteinase 9; metabolism; Placenta Previa; surgery; Pregnancy; Tissue Inhibitor of Metalloproteinase-1; metabolism; Tissue Inhibitor of Metalloproteinase-2; metabolism; Uterus; pathology; Wound Healing; Young Adult
- From: Journal of Southern Medical University 2012;32(9):1336-1340
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the roles of MMPs-9, TIMP-1 and TIMP-2 in cesarean section scar healing.
METHODSThe expressions of the MMPs-9, TIMP-1 and TIMP-2 were detected by EnVision immunohistochemistry in 22 pregnant women with serious complications of the uterine scar, including 8 with early caesarean scar pregnancy (CSP) and 14 with full-term pregnancy undergoing hysterectomy for placenta previa or implanted placenta. Thirty-eight full-term pregnant women without serious complications of the uterine scar and 32 normal full-term pregnant women served as the control I and control II groups, respectively.
RESULTSThe expressions of MMPs-9 and TIMP-1 differed significantly between the 3 groups (P<0.05), whereas TIMP-2 did not (P>0.05). Spearman rank correlation analysis showed that the expression of MMPs-9 in the uterine scar tissues was positively correlated with poor uterine scar healing with the correlation coefficients of 0.309 and 0.643. An increased severity of poor healing scar was associated with a significantly increased expression of MMPs-9 (P<0.05).
CONCLUSIONThe imbalanced expressions of MMPs-9 and TIMP-1 in injury repair can be related to poor uterine scar healing and CSP.
