Clinical value of seminal paraoxonase-1 activity evaluation in the diagnosis of male infertility.
- Author:
Daoyuan GONG
1
;
Ziping LI
;
Xiwei ZHUANG
;
Xiaolin ZHANG
;
Mei KANG
;
Yiping LIAO
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aryldialkylphosphatase; metabolism; Case-Control Studies; Humans; Infertility, Male; diagnosis; metabolism; Male; Semen; metabolism; Semen Analysis; Young Adult
- From: Journal of Southern Medical University 2012;32(9):1355-1357
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the changes in seminal paraoxonase-1 (PON-1) activity in infertile male patients and assess the clinical value of seminal PON-1 examination in the diagnosis of male infertility.
METHODSSeminal PON-1 activity was detected by spectrophotometric method in the semen samples from 270 infertile male patients and 50 health fertile males (control), and the semen parameters were analyzed using a computer-assisted semen analysis system.
RESULTSIn the male infertility group, seminal PON-1 activity was 1.22∓0.76 U/L in the patients with normal semen parameters and 0.64∓0.54 in the patients with abnormal semen parameters, both significantly lower than that of the control group (3.17∓0.89 U/L, P<0.01). In patients with asthenospermia, the declined sperm motility was associated with decreased seminal PON-1 activity, which showed significant differences between patients with mild, moderate, and severe asthenospermia. Seminal PON-1 activity was positively correlated with the percentage of sperm viability (P<0.01), but inversely with the percentage of morphologically abnormal sperm (P<0.01). According to ROC curves, the area of seminal PON-1 activity under the curve was 0.907, showing a statistical significance (P<0.01).
CONCLUSIONThe detection of seminal PON-1 activity can provide a laboratory evidence for the diagnosis of male infertility.