Analysis of infection-related mortality after allogeneic hematopoietic stem cell transplantation in patients with refractory/relapse acute leukemia.
- Author:
Ren LIN
1
;
Jing SUN
;
Yujing MAO
;
Mengxia ZHAO
;
Qifa LIU
;
Hongsheng ZHOU
;
Fen HUANG
;
Xiaoling SONG
;
Han LI
;
Qinghui MA
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Female; Graft vs Host Disease; mortality; Hematopoietic Stem Cell Transplantation; adverse effects; mortality; Humans; Leukemia; mortality; pathology; surgery; Male; Middle Aged; Multivariate Analysis; Mycoses; mortality; Recurrence; Retrospective Studies; Young Adult
- From: Journal of Southern Medical University 2012;32(9):1377-1380
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate infection-related mortality (IRM) after allogeneic hematopoietic stem cell transplantation in patients with refractory/relapse acute leukemia.
METHODSWe conducted a retrospective analysis of 127 patients with refractory/relapse acute leukemia and investigated the incidence, causes and risk factors of IRM.
RESULTSSixty-seven of the patients died after the transplantation. The 5-year overall survival and disease-free survival was (35.2∓5.3)% and (30.8∓5.6)% among these patients, respectively. IRM occurred in 28.3% (36/127) of the patients. Multivariate analysis showed that grade II-IV acute graft-versus-host diseases (aGVDH, P=0.049, OR=3.017) and post-transplant invasive fungal infection (P=0.032, OR=3.223) were independent risk factors of IRM.
CONCLUSIONAs a common cause of transplant-related mortality, IRM is more frequent in cases of refractory/relapse acute leukemia than in cases with a standard risk profile, and effective prophylaxis and treatment of severe GVHD remain currently the primary measures for reducing post-transplant IRM.
