Correlation analysis between serum interleukin-6 and central nervous injury in septic patients.
- Author:
Zhanguo LIU
1
;
Xiaoying TAN
;
Jing CAI
;
Xiangrui YANG
;
Ping CHANG
Author Information
- Publication Type:Journal Article
- MeSH: APACHE; Adult; Aged; Brain Injuries; blood; pathology; Female; Humans; Interleukin-6; blood; Male; Middle Aged; Phosphopyruvate Hydratase; blood; Sepsis; blood
- From: Journal of Southern Medical University 2012;32(10):1451-1453
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the relationship between interleukin-6 (IL-6) production and central nervous injury in septic patients.
METHODSTwenty-two septic patients without central nervous system diseases were examined for serum IL-6 and neuron-specific enolase (NSE) levels, and the serum NSE levels and APACHEII scores were compared between patients with low, moderate, and high serum IL-6 levels. The correlations between NSE, APACHEII and serum IL-6 were analyzed.
RESULTSIn patients with low, moderate, and high serum IL-6 levels, the serum levels of NSE were 10.29∓4.05, 16.06∓5.84 and 23.97∓3.28 µg/L, respectively, showing a significant difference between the 3 groups (P<0.001). The APACHEII scores also differed significantly between the 3 groups (14.17∓4.67, 16.40∓4.84, and 24.00∓6.26, respectively, P=0.009). Correlation analysis showed significant positive correlations of IL-6 with NSE (r=0.788, P<0.001) and with APACHEII scores (r=0.733, P<0.001).
CONCLUSIONIn septic patients, serum IL-6 level is significantly correlated with the severity of sepsis and brain injury, and can be used as a marker to monitor brain injury in septic patients.
