Optimization of solubilizing process of Qingkailing injection based on GA-BPNN modeling.
- Author:
Ruixin LIU
1
;
Nancen LIU
;
Xinyuan SHI
;
Yanjiang QIAO
Author Information
- Publication Type:Journal Article
- MeSH: Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; chemistry; Materia Medica; chemistry; Neural Networks (Computer); Solubility
- From: China Journal of Chinese Materia Medica 2009;34(19):2469-2472
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo optimize solubilizing process of Qingkailing injection.
METHODUniform design experimental method and GA-BPNN modeling method were applied to optimize the technical parameters, and the solubility of cholic acid in medium was taken as optimizing index.
RESULTThe type of solubilizer and pH of medium had greater impact on the index than the concentration for solubilizer. The optimum solubilizer was Tween-80. In a certain range the higher pH of medium was optimum; it was not necessary to use high-concentration solubilizer although there was positive correlation between the index and the concentration of solubilizer.
CONCLUSIONUniform design combined with GA-BPNN modeling method is suitable for optimization of solubilizing process of Chinese materia medica injection, which has certain practical application value.
