Effects of general glycosides in Cynanchum auriculatum of Jiangsu province on liver fibrosis of rats.
- Author:
Weihong LV
1
;
Aixiang ZHANG
;
Shan XU
;
Hongquan ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; China; Cynanchum; chemistry; Drug Evaluation, Preclinical; Drugs, Chinese Herbal; administration & dosage; Glycosides; administration & dosage; Liver; drug effects; pathology; Liver Cirrhosis; drug therapy; pathology; Male; Random Allocation; Rats; Rats, Wistar
- From: China Journal of Chinese Materia Medica 2009;34(19):2508-2511
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effect of general glycosides from Cynanchun auriculatum of Jiangsu on liver fibrosis of rats.
METHODSeventy-two Wistar rats were randomly divided into normal group, model group, BSW three doses treated group and hydrocortisone treated group. CCl4 (50%, 2 mL x kg(-1)) was orally administraeated twice a week for 8 weeks. The liver and spleen indices were observed. The level of serum GPT, GOT, and HA, PCIII and the level of SOD, HyP, MDA in liver homogenates was also measured. The histopathologic change in hepatic of rats was examined.
RESULTThe elevation of serum GPT, GOT, HA, PCIll, MDA and HyP and the content of liver homogenates were attanuated remarkably by BSW treatment. BSW groups also increased the level of SOD of liver homogenates, and make the fibrotic liver better.
CONCLUSIONThe general glycosides in C. auriculatum of jiangsu province have an anti-hepatic fibrosis ettect on CCl4-induced fibrosis rats, the mechanisms might be associated with its anti-oxidative action.
