Preparation and characterization of oridonin submicron emulsions.
- Author:
Li YU
1
;
Xinyong TONG
;
Yan TAN
Author Information
- Publication Type:Journal Article
- MeSH: Chemistry, Pharmaceutical; Diterpenes, Kaurane; chemistry; Emulsions; chemistry; Particle Size; Viscosity
- From: China Journal of Chinese Materia Medica 2009;34(20):2590-2593
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo prepare the oridonin submicron emulsion and characterize their properties.
METHODHigh pressure homogenization method was employed to prepare the oridonin submicron emulsion and such properties as size, Zeta potential and viscosity were characterized.
RESULTThe results showed that the submicron emulsions was formed with the drug loading 1 g L(-1), particle size of (138.87 +/- 0.60) nm, zeta potential of (47.27 +/- 2.31) mV, pH value of (6.02 +/- 0.03) and viscosity of (1.78 +/- 0.015) MPa s, respectively.
CONCLUSIONThe method is feasible and the submicron emulsions has stable properties. Experiments offer a new formulation of oridonin for clinical application.
