Relationship of tetramethylpyrazine on expression of vascular endothelial growth factor and development of adjuvant-induced arthritis in rats.
- Author:
Qiang MA
1
;
Gang CHEN
;
Jifen ZHANG
;
Binbin FENG
;
Xiaoyu XU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Arthritis, Experimental; drug therapy; genetics; metabolism; Disease Models, Animal; Gene Expression; drug effects; Humans; Male; Pyrazines; therapeutic use; Rats; Rats, Wistar; Vascular Endothelial Growth Factor A; genetics; metabolism
- From: China Journal of Chinese Materia Medica 2009;34(21):2799-2802
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the effect of tetramethylpyrazine (TMP) on the expression of vascular endothelial growth factor (VEGF) in the synovium of adjuvant-induced arthritis (AIA) in rats.
METHODAIA rats were treated with different doses of TMP. The effects of treatment were monitored by footpad thickness, contents of tumor necrosis factor-alpha (TNF-alpha) in serum, microvessel density (MVD) and the expression of VEGF protein in the synovium.
RESULTCompared with arthritis model, 100 mg x kg(-1) TMP could remarkably reduce the footpad thickness, contents of TNF-alpha in serum and the expression of VEGF in the synovium.
CONCLUSIONTMP can attenuate the degree of chronic inflammation in AIA rats, and its mechanism might be associated with inhibiting the expression of VEGF.
