Zebrafish--useful model for pharmacodynamics and toxicity screening of traditional Chinese medicine.
- Author:
Aihua LIANG
1
Author Information
1. Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China. liangaihua@sina.com
- Publication Type:Journal Article
- MeSH:
Animals;
Drug Evaluation, Preclinical;
Drugs, Chinese Herbal;
pharmacokinetics;
toxicity;
Medicine, Chinese Traditional;
Models, Animal;
Zebrafish
- From:
China Journal of Chinese Materia Medica
2009;34(22):2839-2842
- CountryChina
- Language:Chinese
-
Abstract:
Zebrafish has been an important model for developmental and genetic studies. In the past ten years, it has also been widely used for environmental toxicity monitoring, additive effect and toxicity of many chemical materials including heavy metals, pesticides, halogenated aromatic hydrocarbon compounds and other carcinogens. Zebrafish is increasingly used in drug screening and toxicological studies in recent years with the advantage of high-throughput handling. It is a useful model of choice for in vivo pharmacodynamic screening and toxicity investigation of Chinese medicine and it has a wide application prospect in the field of new herbal-drug research.
