Research on relationship between angiotensinogen gene M235T and TCM syndrome type in essential hypertension patients.
- Author:
Ying-Xin WAN
1
;
Tie-Zhong ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Angiotensinogen; genetics; China; Diagnosis, Differential; Female; Humans; Hypertension; diagnosis; genetics; Male; Medicine, Chinese Traditional; Middle Aged; Multivariate Analysis; Mutation; Polymorphism, Genetic; Syndrome
- From: Chinese Journal of Integrated Traditional and Western Medicine 2008;28(1):36-38
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the relationship between angiotensinogen (AGT) gene M235T and TCM syndrome type in essential hypertension (ET) patients.
METHODSThe gene mutation frequency of AGT M235T in 168 ET patients and 42 nomotensive (NT) subjects were determined using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique.
RESULTSThere was a significant difference in AGT M235T gene mutation between patients of Gan-fire exuberant type and those of yin-yang deficiency type (P < 0.01), homozygote type TT appeared with higher frequency. Multivariate regression linear analysis demonstrated that the genotypes of AGT M235T was correlated with the prognosis of ET to a certain degree.
CONCLUSIONGene mutation of AGT M235T may be associated with the genesis and development of ET, and the TCM syndrome type of ET has its own intrinsic molecular biological background.
