Clinical study on treatment of recurrent genital herpes by Huangqi Fuzheng Decoction.
- Author:
Yong-Jian SHI
1
;
Xi-Xian DU
;
Chun-Hong ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Cytokines; blood; Drugs, Chinese Herbal; therapeutic use; Female; Herpes Genitalis; blood; drug therapy; pathology; Humans; Interleukin-10; blood; Interleukin-12; blood; Interleukin-18; blood; Interleukin-4; blood; Male; Middle Aged; Phytotherapy; Recurrence; Young Adult
- From: Chinese Journal of Integrated Traditional and Western Medicine 2008;28(3):222-224
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the clinical efficacy of Huangqi Fuzheng Decoction (HQFZD) in treating recurrent genital herpes (RGH) and its influence on related cytokines in peripheral blood.
METHODSEighty-four patients with RGH were randomly assigned to 3 groups, the treated group treated with HQFZD (31 cases), the control group A (25 cases) treated with Aciclovir, and the control group B (28 cases) treated with Aciclovir plus interferon. The course of treatment was 3 weeks for all. The relapse rate was estimated at 6 months after treatment, and levels of IL-4, IL-10, IL-12 and IL-18 in all patients were detected before and after treatment using double-sandwich ELISA.
RESULTSAll patients were cured after treatment. The relapse rate in the treated group and the control group B was lower than that in the control group A (P < 0.01) but insignificant difference was shown between the former two groups. Before treatment, patients' serum levels of IL-4 and IL-10 were significantly higher while those of IL-12 and IL-18 were lower than the normal range (P < 0.01). The abnormal change aforementioned reversed after treatment in the treated group and the control group B (P < 0.05 or P < 0.01), showing a superior effect to that in the control group A (P < 0.01).
CONCLUSIONHQFZD can reduce the relapse rate of RGH without obvious adverse reaction, and it could also enhance the immunity of the patients.