Effect of Tongdatang Serial Recipe on antipsychotic drug-induced galactorrhea-amenorrhea syndrome.
- Author:
Ying DING
1
;
Hui-Zhong QIAN
;
Yi-Qiang WANG
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Amenorrhea; chemically induced; drug therapy; Antipsychotic Agents; adverse effects; Drugs, Chinese Herbal; therapeutic use; Female; Galactorrhea; chemically induced; drug therapy; Humans; Male; Medicine, Chinese Traditional; Middle Aged; Phytotherapy; Schizophrenia; drug therapy; Syndrome; Young Adult
- From: Chinese Journal of Integrated Traditional and Western Medicine 2008;28(3):263-265
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the clinical effect of self-formulated Tongdatang serial recipe (TDT) in treating antipsychotic drug-induced galactorrhea-amenorrhea syndrome (GAS).
METHODSOne hundred female schizophrenic patients with antipsychotic drug-induced GAS were selected and equally assigned to the treatment group and the control group at random. Both received antipsychotic drug-therapy, but combined with TDT and placebo respectively. The efficacy was evaluated by determining prolactin level before, 4 and 8 weeks after treatment.
RESULTSThe treatment course was completed in 96% of patients. Therapeutic efficacy on the 49 patients of the treatment group was cured in 31 (63.3%), markedly effective in 11 (22.4%), effective in 4 (8.2%) and ineffective in 3 (6.1%), with total effective rate of 93.9%, while in 47 patients of the control group, the corresponding cases (%) was 0, 3 (6.4%) , 7 (14.9%) and 37 (78.7%), respectively, with the total effective rate of 21.3%. Prolactin levels in the two groups were insignificantly different before treatment, it reduced in the treatment group after treatment (P < 0.01), and the decrement in the treatment group was more significant than that in the control group (P < 0.05).
CONCLUSIONSatisfactory effect could achieved by using TDT for treatment of antipsychotic drug-induced GAS.
