Study on clinicopathologic features and immunophenotype of 114 cases of renal cell carcinoma.
- Author:
Hong ZOU
1
;
Li-juan PANG
;
Wen-hao HU
;
Feng LI
;
Hong-an LI
;
Jin-fang JIANG
;
Wei-hua LIANG
;
Zhen-zhu SUN
;
Chun WANG
;
Jian-yong LANG
Author Information
- Publication Type:Journal Article
- MeSH: Adenocarcinoma, Clear Cell; pathology; Adolescent; Adult; Aged; Aged, 80 and over; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; genetics; immunology; metabolism; Biomarkers, Tumor; analysis; genetics; Carcinoma, Papillary; immunology; pathology; Carcinoma, Renal Cell; immunology; metabolism; pathology; Female; Gene Fusion; Humans; Immunophenotyping; Kidney Neoplasms; immunology; metabolism; pathology; Male; Middle Aged; Neprilysin; analysis; Racemases and Epimerases; analysis; genetics; Translocation, Genetic; Vimentin; analysis; World Health Organization; Young Adult
- From: Chinese Journal of Pathology 2008;37(11):726-731
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the clinicopathologic features and immunophenotype of renal cell carcinomas, and to discuss their diagnostic value.
METHODSThe clinicopathologic features of 114 cases of renal cell carcinoma were reviewed and categorized on the basis of 2004 WHO classification. Immunohistochemical study for a panel of antibodies (including CK, CD10, vimentin, CD117, AMACR, CK7 and TFE3) was carried out. The follow-up data, if available, were also analyzed.
RESULTSThe cases were reclassified into 5 subtypes, including 77 cases (67.5%) of clear cell carcinoma (CCRCC), 11 cases (9.6%) of papillary renal cell carcinoma (PRCC), 14 cases (12.3%) of chromophobe renal cell carcinoma (chrRCC), 10 cases (8.8%) of renal carcinoma associated with Xp11.2 translocations/TFE3 gene fusions (Xp11.2RCC) and 2 cases (1.8%) of unclassified renal cell carcinoma (unRCC). Immunohistochemical study showed that the expression rates of CK, CD10 and vimentin in CCRCC were 93.5% (72/77), 93.5% (72/77) and 75.3% (58/77), respectively. On the other hand, all the 11 cases of PRCC studied were positive for AMACR. The expression rate of CD117 in chrRCC was 78.5% (11/14). In the 10 cases of Xp11.2 RCC studied, the expression rates of TFE3, AMACR, CD10 and CK were 100% (10/10), 100% (10/10), 90% (9/10) and 70% (7/10), respectively.
CONCLUSIONSThe various subtypes of renal cell carcinomas are heterogeneous in histologic appearance and demonstrate distinctive immunophenotype. The expressions of CD10, vimentin, CD117, AMACR, CK7 and TFE3 are helpful in the differential diagnosis.
