Study on in vitro release and percutaneous absorption for Zhitong cataplasm.
- Author:
Li-Hua SONG
1
;
Mao-Bo DU
;
Shu-Zhi LIU
;
Ke-Ya GE
;
Wen-Ping WANG
;
Qi-Chen CAO
;
Xian-Duan LI
Author Information
1. College of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China. songlihua4835@163.com
- Publication Type:Journal Article
- MeSH:
Administration, Cutaneous;
Animals;
Berberine Alkaloids;
administration & dosage;
chemistry;
pharmacokinetics;
Drugs, Chinese Herbal;
administration & dosage;
chemistry;
pharmacokinetics;
Male;
Mice;
Plant Extracts;
administration & dosage;
chemistry;
pharmacokinetics;
Skin;
metabolism;
Skin Absorption
- From:
China Journal of Chinese Materia Medica
2013;38(14):2306-2308
- CountryChina
- Language:Chinese
-
Abstract:
To evaluate in vitro release and transdermal behaviors of Zhitong cataplasm, modified Franz diffusion cell method was applied to investigate in vitro transdermal absorption of Zhitong cataplasm and the content of tetrahydropalmatine was determined by HPLC. In 24 hours, accumulative release rate of tetrahydropalmatine was 81. 9%, transmission rate was 2.26 microg x cm(-2) x h(-1). In 48 hours, accumulative transdermal rate and transmission rate of tetrahydropalmatine were 20.31%, 0.22 pg x cm(-2) x h(-1). So Zhitong cataplasm had a good release and transdermal properties and transdermal actions were consistent with zero-order kinetics process.
