Chemical constituents from stems of Brucea mollis and their cytotoxic activity.
- Author:
Hui CHEN
1
;
Jian BAI
;
Zhen-Feng FANG
;
Shuang-Gang MA
;
Shi-Shan YU
;
Xiao-Guang CHEN
Author Information
1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
- Publication Type:Journal Article
- MeSH:
Brucea;
chemistry;
Cell Line, Tumor;
Drug Screening Assays, Antitumor;
HT29 Cells;
Hep G2 Cells;
Humans;
Inhibitory Concentration 50;
Plant Extracts;
chemistry;
pharmacology;
Plant Stems;
chemistry;
Plants, Medicinal;
chemistry
- From:
China Journal of Chinese Materia Medica
2013;38(14):2321-2324
- CountryChina
- Language:Chinese
-
Abstract:
Ten compounds were isolated from the stems of Brucea mollis by various chromatographic techniques such as column chromatography on silica gel and Sephadex LH-20, and preparative HPLC, and their structures were elucidated as deacetylated isobrucein B (1), indaquassin X (2), cleomiscosin A (3), cleomiscosin B (4), (+)-lyoniresinol (5), (+)-epipinoresinol(6), (+)-pinoresinol (7), (+)-syringaresinol (8), 4,5-dihydroblumenol A (9) and adenosine (10) on the basis of spectroscopic data analysiS. All compounds were obtained from this plant for the first time, moreover, compound 1 was a new natural product. Compound 2 showed significant cytotoxic activities against the human cell lines HT-29, HepG2, BGC-823 and SKOV3 with IC50 values of 0.84-3.97 micromol x L(-1).