Chemical constituents from Psoralea corylifolia and their antioxidant alpha-glucosidase inhibitory and antimicrobial activities.
- Author:
Tian-Xiao WANG
1
;
Zhen-Hua YIN
;
Wei ZHANG
;
Tao PENG
;
Wen-Yi KANG
Author Information
1. Institute of Chinese Materia Medica, Henan University, Kaifeng 475004, China. wtx1975@126.com
- Publication Type:Journal Article
- MeSH:
Anti-Infective Agents;
chemistry;
pharmacology;
Antioxidants;
chemistry;
pharmacology;
Bacteria;
drug effects;
Enzyme Inhibitors;
chemistry;
pharmacology;
Free Radical Scavengers;
chemistry;
pharmacology;
Glycoside Hydrolase Inhibitors;
Inhibitory Concentration 50;
Plant Extracts;
chemistry;
pharmacology;
Plants, Medicinal;
chemistry;
Psoralea;
chemistry
- From:
China Journal of Chinese Materia Medica
2013;38(14):2328-2333
- CountryChina
- Language:Chinese
-
Abstract:
Twelve compounds were isolated from Psoralea corylifolia and their structures were identified as isopsoralen (1), psoralen (2), 8-methoxypsoralen (3), psoralidin (4), corylin (5), bavachin (6), daidzein (7), corylifolinin (8), bavachinin (9), neobavaisoflavone (10), daidzin (11) and astragalin (12). The results showed that psoralidin had the activity of scavenging DPPH free radicals activity (IC50 43.85 mg x L(-1)). Psoralidin (IC50 1.32 mg x L(-1))c, oryfolin (IC50 4.97 mg x L(-1)), daidzin (IC50 10.47 mg x S(-1)), daidzein (IC50 34.22 mg) x L(-1)) and astragalin (IC50 31.27 mg x L(-1)) had the activity of scavenging ABTS free radical. Psoralidin (IC50 40.74 mg x L(-1)), coryfolin (IC50 45.73 mg x L(-1)) and daidzein (IC50 49.44 mg x L(-1)) had alpha-glucosidase inhibitory activity. Corylifolinin and neobavaisoflavone had significantly effect of inhibiting SA, MRSA and ESBLs-SA (MIC 0. 781 3, 1.562, 5, 0.781 25 microg x disc(-1) and 6.25, 6.25, 6.25 microg x disc(-1).
