Effect of immune 2 with highly active antiretroviral treatment on immune function of HIV/AIDS patients with poor immune reconstitution.

Zhen Liu; Jie Wang; Hong-sheng Lin; Yong LI

Return

Effect of immune 2 with highly active antiretroviral treatment on immune function of HIV/AIDS patients with poor immune reconstitution.

Author: Zhen LIU ¹ ; Jie WANG ; Hong-Sheng LIN ; Yong LI
Author Information

1. Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China. doctorliuzhen@126.com
Publication Type:Journal Article
MeSH: Acquired Immunodeficiency Syndrome; blood; drug therapy; immunology; Adolescent; Adult; Aged; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Drug Therapy, Combination; Drugs, Chinese Herbal; therapeutic use; Female; Humans; Leukocyte Common Antigens; blood; Male; Middle Aged; Treatment Outcome; Young Adult
From: China Journal of Chinese Materia Medica 2013;38(15):2458-2462
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo observe the effection of immune reconstitution efficiency and the immune function on Immune 2 with HAART to HIV/AIDS patients which poor immune reconstitution after HAART.
METHODTwo hundred and sixty four patients failure to immune reconstitution after HAART were randomly divided into treatment group (131 cases) and control group (133 cases), respectively, using Immune 2 plus HAART and placebo combined with HAART for 6 months. the CD4, CD8, CD45RA, CD45RO, CD4CD28, CD8CD28, CD8CD38, HLA-DR and CD4CD25 were observed in order to evaluate the immune reconstitution efficiency.
RESULTAfter the intervention for 6 months, the effective rate of treatment group (34.48%) was significantly superior to the control group (21.37%) (P = 0.0217). Treated group could significantly increased the CD4, CD45RA, CD45RO cell counts compared with control group (P < 0.05); CD8, CD3, CD4CD28 absolute count comparison between the two groups had no significant difference; CD8CD28 relative counting the treatment group group significantly increased (P < 0.05) compared to the control; CD4CD28, CD8CD38, CD8DR, CD4CD25 relative counting groups showed no significant difference.
CONCLUSIONImmune 2 can effectively improve the immune reconstitution efficiency, CD4 counts, CD45RA counts and CD45RO counts of patients after HAART, therefore promoting immune reconstitution.