Study on transdermal characteristics of compound Nanxing pain-relieving cataplasm and effects of gaultherolin in prescriptions.
- Author:
Ying LI
1
;
Shou-Ying DU
;
Yang LU
;
Jie BAI
;
Ying-Zi WANG
;
Yue WANG
;
Yu-Shu XING
;
Wei XIAO
Author Information
- Publication Type:Journal Article
- MeSH: Analgesics; chemistry; metabolism; therapeutic use; Animals; Chemistry, Pharmaceutical; methods; Drugs, Chinese Herbal; chemistry; metabolism; therapeutic use; Mice; Pain; drug therapy; Salicylates; chemistry; Skin; metabolism; Skin Absorption; Time Factors
- From: China Journal of Chinese Materia Medica 2013;38(16):2601-2604
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study transdermal absorption characteristics of eugenol in compound Nanxing pain-relieving cataplasm, and discuss the effect of gaultherolin on the transdermal absorption of the cataplasm.
METHODThe improved franz diffusing cell was adopted with hairless mice skins as transdermal carriers. The content of eugenol in receptor liquid, skins and cataplasm were analyzed by HPLC and compared with the cataplasm without gaultherolin.
RESULTThe penetration rates of eugenol of cataplasms with and without gaultherolin were 13.18 and 9.58 microg x cm(-2) x h(-1), with the retention amount in skins of (185.02 +/- 19.23) and (160.23 +/- 16.54) microg x g(-1) and the retention amount in cataplasms was (1.96 +/- 0.12) and (1.71 +/- 0.15) mg, respectively.
CONCLUSIONEugenol in compound Nanxing pain-relieving cataplasm has good pereutaoeous permeation. Gaultherolin in the cataplasm prescription can promote the absorption of eugenol.
