Levels and clinical significance of CD44 (intron 9) and CD44v6 in malignant cerebroma.

Author: Hong GAO ¹ ; Hui CHEN ; Zhibo ZHANG ; Tao JIANG
Author Information

1. Major Laboratory of Congenital Malformative Research, Health Ministry, Second Affiliated Hospital, China Medical University, Shenyang 110004, China.
Publication Type:Journal Article
MeSH: Adolescent; Adult; Aged; Brain Neoplasms; genetics; metabolism; Child; Child, Preschool; Glycoproteins; biosynthesis; genetics; Humans; Hyaluronan Receptors; biosynthesis; genetics; Introns; genetics; Middle Aged; RNA, Messenger; biosynthesis
From: Chinese Journal of Surgery 2002;40(2):94-96
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo investigate the expression of CD44 (intron 9) and CD44v6 in brain neoplasm.
METHODSCD44 (intron 9) and CD44v6 were detected in malignant meningoma, encephalic glioma, and normal encephalic tissues around the brain noeplasm respectively by using RT-PCR.
RESULTSThe positive expression rate of CD44v6 was 92.86% (26/28) in malignant meningoma and 88.0% (22/25) in encephalic glioma. They were significantly higher than 5.0% (1/20) in normal encephalic tissues (P < 0.01). Mass values of malignant meningoma and encephalic glioma were higher than that of normal encephalic tissues (P < 0.01). The expression of CD44 (intron 9) was higher in malignant meningoma and encephalic glioma than in normal encephalic tissues (P < 0.01).
CONCLUSIONSDetection of CD44 (intron 9) and CD44v6 might be helpful to the diagnosis of malignant cerebroma.