Role of interferon alpha in the management of severe acute pancreatitis.
- Author:
Yaoqing TANG
1
;
Dachuan QI
;
Jun WU
;
Enqiang MAO
;
Jun JI
;
Tianquan HAN
;
Shendao ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Disease Models, Animal; Immunologic Factors; therapeutic use; Interferon-alpha; therapeutic use; Interleukin-10; metabolism; Kidney; metabolism; Male; Pancreatitis, Acute Necrotizing; drug therapy; metabolism; pathology; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha; metabolism
- From: Chinese Journal of Surgery 2002;40(2):146-149
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the efficacy of IFN-alpha on severe acute pancreatitis (SAP) of IFN-alpha.
METHODSA SAP model was developed in adult male rats by retrograde injection of 5% sodium taurocholate in the pancreatic duct. Serum amylase was measured by the blue-starch method and serum cytokines were determined by ELISA.
RESULTSCompared with to the control group, less pancreatic injury and lower amylase level were observed treat in the rats with IFN-alpha. In contrast, the concentration of IL-10 was higher.
CONCLUSIONIFN-alpha has significant curative effect on SAP.
