Application and value of mutation detection in diagnosis and treatment of gastrointestinal stromal tumor.
- Author:
Hui CAO
1
;
Ming WANG
Author Information
1. Department of General Surgery, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China. caohuishcn@hotmail.com
- Publication Type:Journal Article
- MeSH:
Gastrointestinal Neoplasms;
diagnosis;
drug therapy;
genetics;
Gastrointestinal Stromal Tumors;
diagnosis;
drug therapy;
genetics;
Humans;
Mutation;
Proto-Oncogene Proteins c-kit;
genetics;
Receptor, Platelet-Derived Growth Factor alpha;
genetics
- From:
Chinese Journal of Gastrointestinal Surgery
2013;16(3):208-211
- CountryChina
- Language:Chinese
-
Abstract:
Mutation of c-kit and platelet-derived growth factor receptor alpha (PDGFRA) is the most important molecular feature of gastrointestinal stromal tumor (GIST). Mutation detection of these two genes is of great significance when establishing the diagnosis of a kit-negative GIST, or when predicting response to tyrosine kinase inhibitor. Furthermore, more and more researches focus on the feasibility of the mutation status using as a prognostic factor in recent years.
