Competing endogenous RNA regulation mechanism and its role in the development and progression of colorectal cancer.
- Author:
Xian-hua GAO
1
;
Chuan-gang FU
;
Xin-yuan LAO
;
Zhu-jun TAN
Author Information
1. Department of Colorectal Surgery of Changhai Hospital, Second Military Medical University, Shanghai, China.
- Publication Type:Journal Article
- MeSH:
Colorectal Neoplasms;
genetics;
HCT116 Cells;
Humans;
MicroRNAs;
genetics;
PTEN Phosphohydrolase;
RNA, Messenger
- From:
Chinese Journal of Gastrointestinal Surgery
2012;15(12):1318-1321
- CountryChina
- Language:Chinese
-
Abstract:
MicroRNAs are negative regulators of mRNA, and latest studies show that "mRNAs can also inhibit microRNAs". With these reciprocal interactions, different mRNAs with identical "microRNA binding site" cim regulate each other by competitively binding to the same microRNA pool. This is the novel competing endogenous RNA (ceRN A)regulating mechanism. The ceRN A mechanism, which is a totally new regulating mechanism , greatly expands the regulatory network across genes. It has been proved by experimental evidence that, in HCT116 colon cancer cells,KRAS and PTEN , ZEB2 and PTEN can regulate each other by ceRNA mechanism.
