Clinicopathological characteristics and prognostic analysis of bone metastasis in gastric cancer patients.
- Author:
Hui ZHANG
1
;
Ru-peng ZHANG
;
Fang-xuan LI
;
Ji-chuan QUAN
;
Hui LIU
;
Jing-yu DENG
;
Xue-jun WANG
;
Han LIANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Aged, 80 and over; Bone Neoplasms; secondary; Female; Humans; Male; Middle Aged; Prognosis; Retrospective Studies; Stomach Neoplasms; pathology
- From: Chinese Journal of Gastrointestinal Surgery 2013;16(4):354-357
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the clinicopathological characteristics and prognostic factors of bone metastasis in gastric cancer patients.
METHODSClinicopathological data of 66 gastric cancer patients with bone metastasis, who were treated at the Tianjin Medical University Cancer Institute and Hospital from October 1997 to September 2011, were analyzed retrospectively. The clinicopathological characteristics of the primary cancer and bone metastasis were summarized and the prognosis was analyzed.
RESULTSOf 66 patients, 4 underwent operation, 28 chemotherapy, 32 inhibitors of bone resorption,8 local treatment and 23 symptomatic treatment alone. The median survival time of these 66 patients was 5 months (95%CI:3.3-6.7 months). The 1-, 2- and 3-year survival rates were 9.1%, 3.0% and 1.5%, respectively. Univariate Log-rank test indicated that gender, bone metastasis combined with other distant metastasis and chemotherapy were significant prognostic factors (all P<0.05). Multivariate analysis revealed bone metastasis combined with other distant metastasis was an independent prognostic factor (P=0.011, RR=2.067, 95%CI:1.178-3.626).
CONCLUSIONSPrognosis of patients with bone metastasis from gastric cancer is poor. Chemotherapy-based comprehensive treatment may improve the prognosis of these patients.
