Study of radiation synovectomy using (188)Re-Sulfide in hemophilic arthritis.
- Author:
Peiyong LI
1
;
Gang CHEN
;
Liying ZHANG
;
Xufeng JIANG
;
Xuefeng WANG
;
Zhengming SUN
;
Huan ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Chlorides; therapeutic use; Disease Models, Animal; Follow-Up Studies; Hemophilia A; complications; Humans; Injections, Intra-Articular; Rabbits; Rhenium; therapeutic use; Ruthenium Radioisotopes; therapeutic use; Sulfides; Synovial Membrane; radiation effects; Synovitis; etiology; pathology; radiotherapy
- From: Chinese Journal of Hematology 2002;23(3):151-152
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the effectiveness of radiation synovectomy with (188)Re-sulfide.
METHODSTwenty rabbit models of joint synovitis were injected intra-articularly with different doses of (188)Re-sulfide from 7.4 to 37.0 MBq. By pathological examination, the effects of (188)Re-sulfide on synovium and cartilage were evaluated. Clinically, 10 joints of 7 cases of hemophilic arthritis with (188)Re-sulfide radiation synovectomy were performed. MRI was taken before and after the synovectomy to evaluate the treatment effects.
RESULTSIn rabbit models, when (188)Re-sulfide dose larger than 14.8 MBq, the radiation effect on synovitis was remarkable, including thinning the thickened synovium and reducing the inflammatory cells. When radio-activity dose increased to 37.0 MBq, pathological damage was noted in cartilage. Clinical trial demonstrated that radiation synovectomy by (188)Re-sulfide could reduce the frequencies of intra-articular hemorrhage. MRI showed that edema and villi reduced.
CONCLUSIONSRadiation synovectomy using (188)Re-sulfide is effective on synovitis in hemophilic arthritis.
