Indoleamine 2,3-dioxygenase in tumor induced tolerance.
- Author:
Xiao-Qian LIU
1
;
Xin WANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Gene Expression Regulation, Neoplastic; physiology; Humans; Immune Tolerance; physiology; Indoleamine-Pyrrole 2,3,-Dioxygenase; metabolism; Neoplasms; enzymology; immunology
- From: Chinese Medical Journal 2009;122(24):3072-3077
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo review the recent studies about the role of indoleamine 2,3-dioxygenase (IDO) in tumor induced tolerance.
DATA SOURCESPublished articles (1978 - 2009) on IDO and tumor induced tolerance were selected from Medline.
STUDY SELECTIONArticles selected were relevant to development of IDO in tumor induced tolerance. Of all originally identified articles, 50 specially addressed the stated purpose.
RESULTSRecent work has revealed IDO at high levels in tumors and in tumor-draining lymph nodes and a close relationship between IDO activity and the regulatory T cells.
CONCLUSIONUp-regulation of IDO is proven to be a mechanism of acquired tolerance in tumors, in which the closely coupled positive feedback system between IDO and regulatory T cells may be considered to play an important role.
