Clinical and laboratory characteristics of 16 patients with acute lymphoblastic leukemia (ALL) harboring 19p13 abnormalities.
- Author:
Jin-ying GONG
1
;
Xiao-fan ZHU
;
Xu-ping LIU
;
Yu-mei CHEN
;
Yao ZOU
;
Ying-chang MI
;
Jian-xiang WANG
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Child; Child, Preschool; Chromosomes, Human, Pair 1; genetics; Chromosomes, Human, Pair 19; genetics; Female; Humans; Immunophenotyping; Male; Precursor Cell Lymphoblastic Leukemia-Lymphoma; drug therapy; genetics; immunology; Prognosis; Retrospective Studies; Translocation, Genetic; Young Adult
- From: Chinese Journal of Hematology 2009;30(5):294-297
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the clinical and laboratory characteristics of patients with acute lymphoblastic leukemia (ALL) bearing 19p13 abnormalities.
METHODSThe morphologic, immunophenotypic, cytogenetic, and clinal features as well as prognosis of 16 ALL patients with 19p13 abnormalities were retrospectively analyzed. The clinical features and laboratory findings between t(1;19) and der(19) groups were compared.
RESULTSSixteen (4.02%) out of 398 ALL patients had 19p13 abnormalities, among them 15 cases were t( 1;19) (q23;p13) [balanced t(1;19) (q23; p13) in 8 and unbalanced der(19) t(1;19) (q23;p13) in 7] and 1 case t(17;19) (q22;p13). The WBC count and blast cell number were higher in the t(1;19) group. The prognosis was better in der(19) t(1;19) group than in balanced translocation t(1;19) group.
CONCLUSIONThe 19p13 abnormality is one of the non-random chromosomal aberration in patients with ALL. ALL patients with 19p13 abnormalities have unique clinical features and poor prognosis.
