Severe hypercalcemia complicated in acute lymphoblastic leukemia (ALL) with E2A-HLF fusion gene: report of two cases and literature review.
- Author:
Jun YANG
1
;
Xuan ZHOU
;
Bin WANG
;
Chao GAO
;
Rui-dong ZHANG
;
Bin LI
Author Information
- Publication Type:Case Reports
- MeSH: Child; DNA-Binding Proteins; genetics; Female; Humans; Hypercalcemia; etiology; genetics; Infant; Male; Oncogene Proteins, Fusion; genetics; Precursor Cell Lymphoblastic Leukemia-Lymphoma; complications; genetics; Prognosis; Transcription Factors; genetics
- From: Chinese Journal of Hematology 2009;30(9):615-618
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo improve the understanding of severe hypercalcemia complicated in acute lymphoblastic leukemia (ALL) with E2A-HLF fusion gene, and to explore the mechanism of pathogenesis and the relationship between the special gene translocation and severe hypercalcemia.
METHODSTwo patients with severe hypercalcemia complicated in ALL were reported.
RESULTSTwo patients with E2A-HLF fusion gene, which is generated by t(17;19) (q22, p13) translocation, suffered relapse of leukemia three months after chemotherapy, and developed severe hypercalcemia. After further chemotherapy, the hypercalcemia symptoms were corrected or alleviated.
CONCLUSIONSevere hypercalcemia is one of rare complications of ALL. In B cell lymphoblastic leukemia with E2A-HLF fusion gene, the fusion gene showed be closely monitored for evaluating the disease situation.
