Differential expression of CD133, Glut-1 in tissues and endothelial cells derived from infantile hemangioma and vascular malformation.
- Author:
Na LI
1
;
Yu-rong WANG
;
Ai-mei ZHONG
;
Wen-juan WANG
Author Information
- Publication Type:Journal Article
- MeSH: AC133 Antigen; Antigens, CD; metabolism; Glucose Transporter Type 1; metabolism; Glycoproteins; metabolism; Hemangioma; metabolism; pathology; Humans; Peptides; metabolism; Vascular Malformations; metabolism; pathology
- From: Chinese Journal of Plastic Surgery 2007;23(4):324-327
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the expression and significance of CD133, Glut-1 and precursor cell, placental microvessel endothelial cells in the occurrence, development and regression of infantile hemangiomas.
METHODSWe examined the expression and significance of CD133, Glut-1 in the occurrence, development and regression of infantile hemangiomas and congenital vascular malformation postnatal vascular malformation using immunohistochemical technique. An image analysis system (Image-pro plus 5.0) was used to measure the average integrated optical density and the rate of positive area of CD133 and Glut-i in different stages of hemangiomas and in vascular malformation.
RESULTSThe expression of CD133 was significantly higher in differential stages congenital hemangioma, congenital vascular malformation, placenta chorionic villi than postnatal vascular malformation (P < 0.05). About the expression of Glut-1, there was difference between proliferating hemangiomas, placenta and degenerating hemangiomas, vascular malformation (P < 0.05).
CONCLUSIONThe precursor cells marked CD133 is the source of endothelial cells derived from congenital hemangiomas and congenital vascular malformation.
