Effect of HMME-PDT on hyperplastic scar in rabbit ear model.
- Author:
Hong CAI
1
;
Ying GU
;
Jing ZENG
;
Shao-ran LI
;
Ying WANG
;
Dong-wen SHI
;
Lu-yong ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Cicatrix, Hypertrophic; pathology; therapy; Ear; pathology; Female; Hematoporphyrins; pharmacology; Male; Photochemotherapy; Rabbits
- From: Chinese Journal of Plastic Surgery 2007;23(5):425-427
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effect of HMME-PDT (Hematoporphyrin Monomethyl Ether-Photodynamic therapy) on Hyperplastic scar in the rabbit ear.
METHODSThe acute model of dermal Hyperplastic scar in the rabbit ear was established. 24 scars were randomly divided into 2 groups: the experimental group (n = 12) received HMME-PDT treatment, and the controlled group (n = 12) received no special treatment. Specimens were harvested from scars on postoperative 28 day. Scar hyper plasty and collagen fibers were observed by haematoxylin-eosin staining and Van-Gieson staining respectively. The microvessel density was calculated under microscope.
RESULTSCompared with the controlled group, HMME-PDT treatment in the experimental group reduced scar formation, decreased the microvessel density and prevented excess collagen deposition at the wound site.
CONCLUSIONSHMME-PDT may play a role in inhibiting hyperplastic scar in rabbit ear.
