Expression and significance of Ang1, Ang2 and receptor Tie2 in hemangioma.
- Author:
Biao WANG
1
;
Kai-hua LU
;
Ya-nan ZHAO
;
Fu-lian ZHUANG
;
Fan HONG
;
Wen-xiong LIN
;
Jing-an LIN
;
Sheng ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Angiopoietin-1; metabolism; Angiopoietin-2; metabolism; Child, Preschool; Hemangioma; metabolism; pathology; Humans; Infant; Receptor, TIE-2; metabolism
- From: Chinese Journal of Plastic Surgery 2007;23(6):515-518
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the relationship of angiogenesis and the Ang family members/ receptor (Ang/Tie2) in hemangioma.
METHODSExpression of Ang1, Ang2 and the receptor Tie2 was detected with immunohistochemical SP method and RT-PCR method in 17 cases of proliferating hemangioma, 13 involuting cases and 10 cases of normal children skin.
RESULTSThe expression of Ang2 and Tie2 was higher markedly in proliferating hemangiomas than in involuting hemangiomas (P < 0.01), and was rare or negative in normal skin. Expression of Ang1 was rare or negative both in hemangioma and normal skin without significant difference between them (P > 0.05).
CONCLUSIONAng/Tie2 system may play an important role in the proliferating and involuting process of hemangioma.
