The effect of aloesin on melanocytes in the pigmented skin equivalent model.
- Author:
Zhuang-qun YANG
1
;
Zheng-Hui WANG
;
Tie-Liang ZHANG
;
Jun-Bo TU
;
Yong SONG
;
Xiao-Yi HU
;
Guo-Guang LI
Author Information
- Publication Type:Journal Article
- MeSH: Arbutin; pharmacology; Cells, Cultured; Chromones; pharmacology; Flavonoids; pharmacology; Foreskin; cytology; Glucosides; pharmacology; Humans; Male; Melanins; biosynthesis; Melanocytes; drug effects; Phenols; pharmacology; Pigmentation; Polyphenols; Skin; drug effects; Skin Aging; drug effects
- From: Chinese Journal of Plastic Surgery 2008;24(1):50-53
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the effect of aloesin, tea polyphenols, arbutin on melanocytes in the pigmented skin equivalent model.
METHODSFirst, we constructed the pigmented skin equivalent model in vitro. And then we detected the effect of aloesin, tea polyphenols and arbutin on the cells' shape, tyrosinase activity and formation of melanin in the constructed pigmented skin equivalent.
RESULTSThree depigmenting agents showed an inhibition effect on the tyrosinase activity of melanocytes and reduced significantly melanin content in the pigmented skin equivalent model, in which the tea polyphenols had the strongest effect, and then was the aloesin. But the tea polyphenols showed the strongest toxicity, while the aloesin and arbutin had a much lower toxicity.
CONCLUSIONSAll the three depigmenting agents showed a concentration dependent suppression effect on the tyrosinase activity and formation of melanin, in which the tea polyphenols was the strongest effect( P <0.05). Aoesin has a good suppression effect on the tyrosinase activity and formation of melanin, but has a much lower toxicity, which could be used as a safe depigmenting agent.
