Effect of Yangqixue Qufengshi Recipe on rheumatoid arthritis model mice under different genetic backgrounds.
- Author:
Fen LI
1
;
Hong WU
;
Jun-wei DENG
;
Song-qing FAN
;
Jing TIAN
;
Jie-sheng GAO
;
Ya-hui ZHU
;
Guang-xiu LU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Antibodies; blood; Antirheumatic Agents; therapeutic use; Arthritis, Experimental; drug therapy; Arthritis, Rheumatoid; drug therapy; immunology; pathology; Collagen Type II; immunology; Drugs, Chinese Herbal; therapeutic use; HLA-DR4 Antigen; genetics; Mice; Mice, Inbred Strains; Mice, Knockout
- From: Chinese journal of integrative medicine 2006;12(1):46-49
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo study the effect of Yangqixue Qufengshi Recipe (YQXQFS) on rheumatoid arthritis (RA) model mice under different genetic backgrounds.
METHODSCollagen Induced Arthritis (CIA) were established on HLA-DR4 transgenic (TG) mice and non-transgenic (NTG) mice, which partly were raised with YQXQFS, and the onset day of CIA, the level of type II collagen (CII)-reactive antibodies and the pathological scores of CIA were assessed.
RESULTSUnder HLA-DR4 TG background (compared with NTG mice), the earlier onset day of CIA (11.22 +/- 3.35 days vs 16.56 +/- 4.75 days, P < 0.05) and higher level of CII-reactive antibodies (0.2274 +/- 0.1390 microg/ml vs 0.1101 +/- 0.0560 microg/ml, P < 0.05) were observed, but the pathological scores of CIA remained unchanged. YQXQFS could not influence the onset day of CIA and the level of CII-reactive antibodies, but had a certain effect on the total pathological scores (6.56 +/- 3.43 scores vs 11.11 +/- 5.64 scores) and bone erosion (0.22 +/- 0.44 scores vs 1.67 +/- 1.50 scores) of CIA on NTG mice (P < 0.05), NTG YQXQFS group compared with NTG experimental group.
CONCLUSIONYQXQFS had a certain effect on RA model, but had no significant effect on HLA-DR4 related CIA.
