A prospective multicenter randomized study on prophylactic antibiotics use in cesarean section performed at tertiary center.
10.5468/kjog.2010.53.3.227
- Author:
Ji Kyung KO
1
;
Yong Kyoon CHO
;
Hye Jin YANG
;
Chan Wook PARK
;
Joong Shin PARK
;
Jong Kwan JUN
;
Min Gyun KIM
;
Hye Sung WON
;
Pil Ryang LEE
;
Ahm KIM
Author Information
1. Department of Obstetrics and Gynecology, Sanggyepaik Hospital, Inje University College of Medicine, Seoul, Korea. ymkcho@paik.ac.kr
- Publication Type:Multicenter Study ; Original Article ; Randomized Controlled Trial
- Keywords:
Prophylactic antibiotics;
Cesarean section;
Infectious morbidity
- MeSH:
Abscess;
Anti-Bacterial Agents;
Antibiotic Prophylaxis;
Cesarean Section;
Constriction;
Endometritis;
Female;
Humans;
Length of Stay;
Pneumonia;
Pregnancy;
Pregnant Women;
Prospective Studies;
Sepsis;
Skin;
Track and Field;
Wound Infection
- From:Korean Journal of Obstetrics and Gynecology
2010;53(3):227-234
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: To determine whether the duration and timing of prophylactic antibiotics influence maternal postoperative infectious morbidity in cesarean section performed at tertiary center. METHODS: This study was a prospective, randomized trial. Pregnant women who underwent cesarean section between December 2008 and September 2009 at tertiary center were enrolled and divided into two groups: Group A, antibiotic prophylaxis was applied for 24 hours and Group B, antibiotic prophylaxis was applied for 48 hours. First generation of cephalosporin was administrated within 30 minutes prior skin incision or after cord clamping. The occurrence of postoperative infectious morbidity such as febrile morbidity, wound infection, endometritis, urinary track infection, pneumonia, sepsis and pelvic abscess and hospital stays were compared. RESULTS: There were 413 pregnant women enrolled and then randomized into 220 for group A and 197 for group B. No demographic differences were observed between two groups. The infectious morbidity was 1.9% (8/413) and wound infection was the most common postoperative infections morbidity. No significant difference was found between the groups for infectious morbidity and hospital stays. Also timing of prophylactic antibiotics did not result in significant difference for infectious morbidity. CONCLUSION: Short course of prophylactic antibiotics has been shown to be as efficacious as multidose of prophylactic antibiotics for preventing infectious morbidity in cesarean section and timing did not influence on infections morbidity. Further studies focusing on duration and timing of prophylactic antibiotics for cesarean section are needed.
