Association between hepatitis B virus infection and risk of pancreatic cancer: a meta-analysis.
- Author:
Han ZHUANG
1
;
Zhipeng SHI
;
Peng HU
;
Hong REN
;
Dazhi ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Hepatitis B; epidemiology; Hepatitis B Surface Antigens; blood; Hepatitis B virus; Humans; Pancreatic Neoplasms; epidemiology; virology; Risk Factors
- From: Chinese Journal of Hepatology 2014;22(6):416-419
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the relationship between hepatitis B virus (HBV) infection and risk of pancreatic cancer.
METHODSVarious English and Chinese language literature databases, including PubMed, Web of Knowledge, Embase, Cochrane Library and the Chinese National Knowledge Infrastructure, were searched for case-control studies comparing rates of HBV infection and pancreatic cancer. The RevMan meta analysis software, version 5.0, was used to perform the meta-analysis of the 6 included studies.
RESULTSCompared with the control group, the pancreatic cancer group had a significantly higher rate of positivity for hepatitis B surface antigen (HBsAg) (8.87% vs.5.86%, odds ratio (OR) =1.24, 95% confidence interval (CI):1.06 to 1.47, P =0.009) and a lower rate of patients never exposed to HBV (defined as HBsAg(-)/hepatitis B core antibody (anti-HBc)(-) (69.4% vs.77.1%, OR =0.68, 95% CI:0.51 to 0.92, P =0.01). There was no significant difference between the two groups in the rate of hepatitis B e antigen positivity (P =0.55).
CONCLUSIONHBV-infected patients with HBsAg(+) status are at greater risk of developing pancreatic cancer; however, since most of the research studies evaluated were conducted in Asians, the generalizability of this conclusion is unknown.
