Clinical significance of hepatitis B virus S gene mutation for recurrence of hepatitis B after liver transplantation.
- Author:
Zuoyi JIAO
1
;
Donghong ZHANG
;
YmMin LI
;
Changjiang LUO
;
Lvnan YAN
Author Information
- Publication Type:Journal Article
- MeSH: Adult; DNA, Viral; genetics; Female; Genetic Variation; Hepatitis B; virology; Hepatitis B virus; genetics; Humans; Liver Transplantation; Male; Middle Aged; Mutation; Postoperative Period; Recurrence; Viral Envelope Proteins; genetics
- From: Chinese Journal of Hepatology 2014;22(8):580-584
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo examine the incidence of hepatitis B virus (HBV) S gene mutation in recipients with recurrent HBV infection after liver transplantation (LT) and to evaluate the clinical significance of these mutants.
METHODSTwo-hundred-and-ninety-nine patients who received LT for HBV-related liver diseases in single centre were enrolled in the study and followed up. Serum HBV DNA was amplified by fluorescence quantitative polymerase chain reaction, and HBV-S gene mutation was detected by Sanger's enzymatic method.
RESULTSTwelve of the 299 patients developed recurrent HBV after LT, and 2 of these 12 carried a mutant of the HBV-S gene (incidence rate of 16.67%). One of the patients had T126I and G145A mutations, and the other had a M 133L mutation. Cox regression modelling identified the risk factors of HBV recurrence after LT as HBV-YMDD mutants (P =0.01), HBV-S mutants (P =0.03) and compliance decrease (P =0.03).
CONCLUSIONHBV-S mutants may contribute to recurrence of HBV after LT, and the mechanism should be addressed in future studies.
