Expression of T-bet and its regulation on CD4(+) T cell polarization in aplastic anemia.
- Author:
Hai-Li WANG
1
;
Wu WEI
Author Information
1. Department of Hematology, Shanxi Medical University Second Clinical Medical College, Taiyuan 030001, Shanxi Province, China.
- Publication Type:Journal Article
- MeSH:
Anemia, Aplastic;
blood;
immunology;
CD4-Positive T-Lymphocytes;
immunology;
metabolism;
Humans;
Lymphocyte Count;
T-Box Domain Proteins;
immunology;
metabolism;
Th1 Cells;
immunology;
metabolism
- From:
Journal of Experimental Hematology
2011;19(2):546-549
- CountryChina
- Language:Chinese
-
Abstract:
Aplastic anemia (AA) is an autoimmune disease which take hematopoietic tissue as target cells. T lymphocyte-mediated cellular immune abnormality plays a key role in the pathogenesis of AA. Increase and hyperfunction of Thl lymphocytes are main feature of AA disease. The recent studies indicated that T-bet is Th1 cell-specific transcription factor, is crucial factor for polarization of CD4(+) T lymphocytes to Th1. High expression of T-bet in AA patients is an important link in pathogenesis of AA. In this article, T-bet and its relation with AA, including expression of T-bet in AA patients, the regulation of T-bet on polarization of CD4(+) T lymphocytes are reviewed.
