Release of CD44-proteolytic fragments and their functions.
- Author:
Da-Yan CHEN
1
;
Ru FENG
Author Information
1. Department of Hematology, Nanfang Hospital, Nanfang Medical University, Guangzhou 510515, Guangdong Province, China.
- Publication Type:Journal Article
- MeSH:
Hyaluronan Receptors;
metabolism;
Hydrolysis
- From:
Journal of Experimental Hematology
2011;19(2):554-556
- CountryChina
- Language:Chinese
-
Abstract:
CD44 is a widely distributed cell-adhesion molecule that participates in a number of biological events. CD44 is proteolytically cleaved by other enzymes and the level of its proteolysis is correlated to the cell activity. The CD44-proteolytic peptides including soluble CD44 and CD44 intracellular domain have different functions in cell events. In recent years, a number of researches found the functions of CD44-proteolytic peptides. In this review, the release of CD44-proteolytic peptides and their functions of these peptides were summarized.
