1059 g/c gene polymorphism of C-reactive protein in patients with deep vein thrombosis.
- Author:
Mei-Fang WANG
1
;
Lin-Hua YANG
;
Xiao-Ling YANG
;
Rui-Juan ZHANG
;
Chun-Xia DONG
;
Li-Hong HOU
;
Xiu-E LIU
Author Information
1. Department of Hematology, Shanxi Medical University Second Hospital, Taiyuan 030001, Shanxi Province, China.
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Aged;
Aged, 80 and over;
C-Reactive Protein;
genetics;
Case-Control Studies;
Exons;
Female;
Gene Frequency;
Genotype;
Humans;
Male;
Middle Aged;
Polymorphism, Restriction Fragment Length;
Venous Thrombosis;
genetics;
Young Adult
- From:
Journal of Experimental Hematology
2011;19(3):769-771
- CountryChina
- Language:Chinese
-
Abstract:
This study was aimed to investigate the distribution of 1059 G/C gene polymorphism of C-reactive protein(CRP) in deep vein thrombus (DVT) and its clinical significance. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to screen 1059 G/C polymorphism in exon 2 of C-reactive protein gene in 61 cases of DVT and 60 healthy controls. The frequency of mutation was calculated. The results showed that there was no statistical difference of 1059 G/C genotype and mutation frequency of allele between deep vein thrombosis group and control group (p > 0.05). It is concluded that the 1059 G/C gene polymorphism of CRP displays certain difference in races and areas, and whether 1059 G/C gene polymorphism of CRP is a dangerous factor for deep vein thrombosis, which needs to be deeply explored.
