Correlation of killer immunoglobulin-like receptor gene diversity with nasopharyngeal carcinoma in Chinese southern Han population.
- Author:
Liang LU
1
;
Shi-Zheng JIN
;
Da-Ming WANG
;
Su-Qing GAO
;
Zi-Hui DENG
Author Information
1. Shenzhen Blood Center, Shenzhen 518035, Guangdong Province, China. 339271353@qq.com
- Publication Type:Journal Article
- MeSH:
Adult;
Aged;
Asian Continental Ancestry Group;
genetics;
Case-Control Studies;
Female;
Gene Frequency;
Genotype;
Humans;
Male;
Middle Aged;
Nasopharyngeal Neoplasms;
genetics;
Receptors, KIR;
genetics;
Receptors, KIR2DL3;
genetics;
Receptors, KIR2DL5;
genetics
- From:
Journal of Experimental Hematology
2011;19(3):798-800
- CountryChina
- Language:Chinese
-
Abstract:
The objective of this study was to elucidate the correlation of killer immunoglobulin-like receptor (KIR) gene diversity with nasopharyngeal carcinoma (NPC) in the Chinese southern Han population. KIR genotyping of peripheral blood samples from 67 patients with NPC and 77 randomly-selected healthy controls was performed by PCR-SSP, the relative risk (RR) value was calculated by means of Wolf method. The results showed that the KIR2DL3 gene frequency in NPC patient group was significantly lower than that in healthy controls (χ²>3.84, p < 0.05, RR = 0.08), whereas the KIR2DS5 and KIR2DL5B gene frequencies in patient group were significantly higher than those in healthy controls (χ²>3.84, p < 0.05, RR > 1), the other KIR gene frequencies were no statistically different between two groups. It is concluded that the KIR2DL3, KIR2DS5 and KIR2DL5B genes may be correlated with pathogenesis of NPC in the Chinese southern Han population.
