Effect of ABO-incompatible allogeneic stem cell transplantation on erythroid lineage hematopoiesis.
- Author:
Xue-Jiao CAI
1
;
Jun-Yin HONG
;
Yi CHEN
;
Kang YU
Author Information
1. Department of Blood Transfusion, The First Affiliated Hospital of Wenzhou Medical College, Wenzhou 325000, Zhejiang Province, China.
- Publication Type:Journal Article
- MeSH:
ABO Blood-Group System;
immunology;
Adult;
Blood Group Incompatibility;
blood;
immunology;
Erythrocytes;
immunology;
Female;
Hematopoiesis;
Hematopoietic Stem Cell Transplantation;
methods;
Humans;
Male;
Transplantation, Homologous
- From:
Journal of Experimental Hematology
2011;19(3):801-804
- CountryChina
- Language:Chinese
-
Abstract:
This study was purposed to investigate the effect of ABO-incompatible allogeneic hematopoietic stem cell transplantation (allo-HSCT) on erythroid lineage hematopoiesis. The changes of ABO group, IgM and IgG antibody in 16 patients received ABO-incompatible allo-HSCT were detected. The results showed that ABO-incompatible allo-HSCT were successfully engrafted in 16 patients, and there was no difference in reconstitution of platelets and neutrophils between ABO-incompatible and ABO-compatible transplantation (p > 0.05). The time of erythroid lineage reconstitution was prolonged (p < 0.05), the disappearance time of isoagglutinins against donor-type RBC in major and bidirectional ABO-incompatible recipients was correlated with the time of erythroid lineage reconstitution. It is concluded that ABO-incompatible allo-HSCT may lead to prolong recovery of erythroid lineage hematopoiesis. Before transplantation, the removal of anti-donor isoagglutinins by plasmapheresis or transfusion of donor's erythrocytes for neutralizing the isoagglutinins against donor's erythrocytes in the recipients may facilitate RBC engraftment and reduce erythrocyte transfusion.
