Veto T cells enhance engraftment allogeneic hematopoietic stem cells.
- Author:
Feng LI
1
,
2
;
Lian-Ning DUAN
;
Shu-Quan JI
Author Information
1. Department of Hematolgy, Chinese PLA Air Force General Hospital, Beijing 100142, China
2. The Fourth Military Medical University, Xi'an 710032, Shaanxi Province, China.
- Publication Type:Journal Article
- MeSH:
Hematopoietic Stem Cell Transplantation;
Humans;
Immune Tolerance;
T-Lymphocytes, Cytotoxic
- From:
Journal of Experimental Hematology
2011;19(3):824-827
- CountryChina
- Language:Chinese
-
Abstract:
Veto activity was defined as the capacity of specifically downregulating cytotoxic T-precursor cell (CTL-p) directed against antigens of the veto cells themselves but not against third-party antigens. Many studies have shown that the most potent veto cells are CD8(+) cytotoxic T lymphocytes (CD8(+)CTLs). Effectively, CD8(+)CTLs of donor origin can facilitate engraftment of donor's stem cells by eliminating host-alloreactive T lymphocytes. In this article, effect mechanisms, depletion of GVH ex vivo, application in vivo, synergistic enhancement with rapamycin and regulatory T cells, and anti-tumor effect in the hematopoietic stem cell transplantation are summarized.
