Research progress of tumor microenvironment and non-Hodgkin's lymphomas.
- Author:
Jing-Xia CHEN
1
;
Jun-Min LI
Author Information
1. Department of Hematology, Ruijin Hospital of Shanghai Jiaotong University Medical College, Shanghai 200025, China.
- Publication Type:Journal Article
- MeSH:
Cytokines;
immunology;
Dendritic Cells;
immunology;
Humans;
Lymphoma, Non-Hodgkin;
immunology;
Macrophages;
immunology;
T-Lymphocyte Subsets;
immunology;
Tumor Microenvironment
- From:
Journal of Experimental Hematology
2011;19(3):843-847
- CountryChina
- Language:Chinese
-
Abstract:
Non-Hodgkin's lymphoma cells including lymphoma stem cells reside in a specific microenvironment in which a series of nonmalignant bystander cells and cytokines play a crucial role in the genesis and development of non-Hodgkin's lymphomas. In addition, tumor microenvironment has important prognostic significance in Non-Hodgkin's lymphomas. Blocking the cross-talk between the tumor microenvironment and lymphoma cells may thus represent a promising new strategy for treating Non-Hodgkin's lymphomas. This review summarizes the current advance in studies of the tumor microenvironment and non-Hodgkin's lymphomas, including cells in tumor microenvironment, role of mesenchymal stem cells and stromal cells, auxiliary role of T cell subsets, macrcphage and dentritic cells, cytokines, immune surveillance and so on.
