OBJECTIVETo evaluate influence of assemble flavone of rhizome drynaria (AFDR) on the value of the blood serum alkalinity phosphatase (ALP), calcium (Ca), phosphorus (P), creatinine (Cr) and glutamic-pyruvic transaminase (GPT) in rats model with skull defects.

METHODSSixty SD male rats with age of 6-month were feeded for a week and then were randomly divided into control group and AFDR group, with 30 rats in each group. Left and right skull of rats were perforated with electromotive drill and the model of skull defects was made. Injectable bone regeneration vomposite (IBRC) was implanted right skull defects. The rats of control group and AFDR group were respectively lavaged with AFDR and deionized water at the first day after operation. The rats were respectively killed at the 2nd,4th and 8th week and the blood serum ALP, Ca, P, Cr, GPT were detected and analyzed by statistics.

RESULTSAt the 2nd week after operation, blood serum ALP in AFDR group was higher than that of control group. At the 4th week after operation, blood serum Ca, P, and calcium-phosphorus product in AFDR group was higher than that of control group; there was no significant difference in GPT between two groups. At the 8th week after operation, blood serum Cr in AFDR group was lower than that of control group.

CONCLUSIONWhen AFDR is used in the repairing of bone defect for 2-4 weeks, it may affect the level of ALP, Ca, P, and without toxicity to liver and kindey.