Effects of Dexamethasone on Endothelin-1(ET-1) Production by Keratinocytes.
10.5021/ad.2001.13.3.148
- Author:
Il Whan LEE
;
Seung Chul LEE
;
Dong Seok KIM
;
Hye Jin KIM
;
Kyoung Chan PARK
- Publication Type:Original Article
- MeSH:
Cytokines;
Dexamethasone*;
Endothelin-1;
Glucocorticoids;
Keratinocytes*;
Lincomycin
- From:Annals of Dermatology
2001;13(3):148-152
- CountryRepublic of Korea
- Language:English
-
Abstract:
Epidermal keratinocytes are important sources of a wide variety of cytokines that include the endothelin-1 (ET-1). Glucocorticoids have been shown to inhibit the production of several cytokines. However, their effect on ET-1 synthesis by keratinocytes is still unknown. It has been reported that ultraviolet B (UVB) irradiation stimulates both the synthesis and release of ET-1 and it was observed that ET-1 secretion by HaCat cells increased with increasing UVB exposure. In this study, the effects of glucocorticoid on ET-1 production were evaluated using cultured HaCat keratinocytes. The results showed that dexamethasone suppressed basal re-lease of ET-1. In addition, it strongly inhibited the UVB-mediated augmentation of ET-1 production. Furthermore, lincomycin slightly enhanced the inhibitory effect of dexamethasone on ET-1 synthesis.
