Association between genetic polymorphism in xeroderma pigmentosum G gene and risks of laryngeal and hypopharyngeal carcinomas.
- Author:
Shu-xin WEN
1
;
Ping-zhang TANG
;
Xue-mei ZHANG
;
Dan ZHAO
;
Yong-li GUO
;
Wen TAN
;
Dong-xin LIN
Author Information
- Publication Type:Journal Article
- MeSH: Case-Control Studies; Female; Genetic Predisposition to Disease; Genotype; Humans; Hypopharyngeal Neoplasms; genetics; pathology; Laryngeal Neoplasms; genetics; pathology; Male; Polymorphism, Genetic; Xeroderma Pigmentosum Group D Protein; genetics
- From: Acta Academiae Medicinae Sinicae 2006;28(5):703-706
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the association between polymorphism of DNA repair gene xeroderma pigmentosum G (XPG) Asp1104His and the risks of developing laryngeal and hypopharyngeal carcinomas.
METHODSTotally 175 patients with laryngeal or hypopharyngeal carcinoma and 525 cancer-free controls were genotyped for the polymorphism by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The odds ratio (OR) and 95% confidence interval (CI) were calculated using unconditional logistic regression model.
RESULTSCompared with those having the Asp/Asp genotype, patients having the XPG 1104Asp/His genotype had a higher risk for laryngeal carcinoma (OR = 2.46, 95% CI = 1.15-5.24, P < 0.05), but not for hypopharyngeal carcinoma (OR = 1.36, 95% CI = 0.87-2.12, P > 0.05). In addition, the XPG 1104Asp/His genotype appeared to be associated with well differentiated squamous cell carcinoma in both larynx and hypopharynx (OR = 1.88, 95% CI = 1.05-3.40, P < 0.05 ).
CONCLUSIONThe XPG Asp1104His polymorphism may play a role in the development of laryngeal and hypopharyngeal carcinomas.
